The lab is organizing the second Annual Meeting of the COST action CA18103 Innogly (Innovation with glycans), which will be held from 4th to 6th May 2002 at the new Campus Est USI SUPSI in via la Santa 1 in Lugano. More information can be found in the website of the conference:


We published on PNAS! Click on link to have more information:

M. Serulla, G. Ichim, F. Stojceski, G. Grasso, S. Afonin, T. Schober, R. Roth, C. Godefroy, P.E. Milhiet, K. Das, A.G. Saez, A. Danani and C. Widmann, “TAT-RasGAP 317-326 kills cells by targeting inner leaflet-enriched phospholipids”, PNAS , DOI: 10.1073/pnas.201410811


Download the program: Program Forum AI 09 October 2019
Elucidating the role of surface chemistry on cationic phosphorus dendrimer-siRNA complexation“, Plenary Lecture at Biodendrimer 2018, Urbino, 4-7 June 2018
Partecipation at SGE Investment Forum, Rohrschach, April 24th:

Presentation “Where AI and Big Data can help us to understand faster and better”

Panel “Customer Focus and Transparency” with Eric Jacob, Ruth Metzler and Sven Bradke

Dendrimers as siRNA delivery systems and inhibitors of amyloids aggregation. A molecular modelling approach.” at ISN2A, Lisbon, 22-25 January 2018

Nuovo Polo tecnologico in AI dell’UBS (notizie sui media e interviste, 17 gennaio 2918)

RSI – Il Quotidiano (min 4.30 ca.) – 19.00

Teleticino – TGTalk – (min. 3.00 ca.) – 19.45
Link (dal minuto 2:50):
Biocompatible Dendrimeric polymers to prevent amyloid-peptide fibril formation induced by CU(II): a multisciplinary study” at Modern Trends in Dendrimer Chemistry and Applications, Moscow, 2-4 October 2017
Molecular Modeling as virtual microscope: some examples with dendrimeric structures in interaction with siRNA, viruses and amyloids “, seminar given in the Doctoral School at University of Sassari, 20 June 2017.
How hybrid dendrimer nanoparticle affect amyloid αβ1-40 aggregation in presence of copper ions: a computational study
at “New Trends in nanomedicine”, International School of Nanomedicine, Erice, 8-13 April 2017
Partecipation to Zuerich Economic Impulse, Rueschlikon, 29 March 2017
Panel “Digitale Transformation”:

Multiscale Approach for the Study of Ghrelin and Toll Like 7 Receptor Ligands
at the 1st MuTaLig COST Action Training School: Computational Approaches to Polypharmacology
Pharmaziezentrum UZA2, University of Vienna, 8-10 February 2017
MC and WG meetings of COST Action CA15135
CTI Project with Microsphere SA “Arcadia” approved!
31 January 2017
Molecular Modeling as virtual microscope: some examples with dendrimers in interaction with siRNA, viruses and amyloids
at LCC-CNRS, Université de Toulouse, 23 January 2017
at UMR CNRS 8612 Institut Galien Paris-Sud, 7 November 2016
MC and WG meetings of COST Action MP1202, Aveiro (Portugal)
10 – 12 October 2016
Investigating the constitutive activity of Ghrelin Receptor by Molecular Modeling
at BMT 2016, “Dreiländertagung”, Swiss, Austrian 
and German Societies of Biomedical Engineering
Congress Center Basel, 4 – 6 October 2016
SER-COST project in collaboration with Université Paris-Sud (Prof. E. Fattal) approved!
9 September 2016
Optimization of gene and drug delivery systems using Molecular Dynamics: some examples“,
at Swiss Physical Society- SPS Annual Meeting, USI – Lugano, 23 – 25 August 2016
I joined on August 3d 2016 the Management Committee as MC substitute for Switzerland of the EU Cost Action CA 15135 “MUTALIG”.
Investigating the constitutive activity of Ghrelin Receptor by Molecular Modeling“,
at CECAM Workshop “Understanding function of proteins in membrane by atomistic and multiscale simulations”, USI- Lugano, 10 – 12 November 2015
MC and WG meetings of EU COST action MP1404, Parma,
12 – 13 October 2014
I joined on May 5th the Management Committee of the EU Cost Action MP 1404 “Simulation and pharmaceutical technologies for advanced patient-tailored inhaled medicines (SimInhale)”
and have been designated member of the steering committee as coordinator of Dissemination and Outreach of the Action
“Supporting the Design of Efficient Drug Nanocarriers with Molecular Modeling: some Examples”
given at:
School of Pharmaceutical Sciences (EPGL), University of Geneva, University of Lausanne, Biopharmaceutical Sciences, 5 December 2014, Geneva
Nanostructured Functional Materials Group (NanoSFun), Centro de Investigación en Nanociencia y Nanotecnologia (CIN2-CSIC), Institut Català de Nanociència i Nanotecnologia (ICN2),
1 December 2014, Bellaterra (Barcelona), Spain

“Molecular Modeling to study and optimize Drug Delivery Systems”
at the 1st International Conference:
“From drug discovery to Drug Delivery”
13 – 15 November 2014, Athens, Greece
“Biofunctionalization Strategies of Magnetic Nanoparticles by Molecular Modeling ”
at the last Workshop of Cost Action “Bio-inspired nanotechnologies” TD1003:
Bioinspired Materials Conference,
20-21 October 2014, Ankara, Turkey
Bilkent University, Institute of Materials Science and Nanotechnology (UNAM)
“Molecular Modeling for Investigating Magnetic Nanoparticles Biofunctionalization Strategies”
at the Workshop of HINT Cost Action:
Integrated approaches for biomolecular detection: nanostructures, biosensors and lab-on-chip devices
15 – 17 September 2014, Istanbul, Turkey

Pictures of the conference

Biodendrimer 2014 – 4th International Symposium on Biomedical Applications of Dendrimers
June 18-20, Lugano, Palazzo dei Congressi
at the Workshop of Cost Action “Bio-inspired nanotechnologies” TD1003:
Integrated approaches for biomolecular detection: nanostructures, biosensors and lab-on-chip devices
28 – 30 aprile 2014, Scuola Superiore di Catania
Seminario SUPSI
TITLE: GPCR heterodimerization leads to opioid-induced hyperalgesia.
SPEAKER: Dr. Marino Convertino – University of North Carolina – Department of Biochemistry and Biophysics
DATE: Wednesday, 9 October 2013
PLACE: SUPSI-DTI, Galleria 2, Sala Primavera (Ground floor, Nord Entry)
TIME: 16.45-17.30
ABSTRACT: Opioids are the most prescribed and effective drugs for treatment of moderate and severe pain. Despite their pharmacological efficacy, the use of opioids in therapy is compromised by the onset of significant side effects as opioid-induced hyperalgesia. We have recently discovered a new isoform of μ-opioid receptor, which consists of six trans-membrane helices (6TM-mOR) that is able to dimerize with β2 adrenergic receptor (b2AR). Upon migration on the cellular surface, the 6TM/b2AR heterodimer is activated by morphine and leads to the development of severe opioid-induced hyperalgesia. Such finding can drive through the therapeutic use of classical beta-blockers in the treatment of chronic pain.
Intervista al TG sul bosone di Higgs (8 ottobre 2013)
Link: Intervista al TG
Seminario SUPSI
TITLE: A fusion of systems biology and physical structure approaches to rational drug design
SPEAKER: Dr. Avner Priel-  University of Alberta – Edmonton, Canada
DATE: Wednesday, 31 July 2013
PLACE: SUPSI-DTI, Galleria 2, Room 230 (2nd floor)
TIME: 11.15-12.00

ABSTRACT: In recent years two computational intensive approaches evolved; At the molecular level, in-silico rational drug design methods have been developed to suggest novel chemotherapeutic agents. The methods include compound library design, homology modeling, binding site prediction, etc. Binding affinity prediction is being performed with docking techniques, molecular dynamics, and hybrid quantum mechanics/molecular mechanics approaches. At a higher level, the systems biology approach aims at modeling the highly interconnected nonlinear characteristics of biological systems. These efforts span many types of intra- and inter- cellular networks. I order to design and test in-silico new chemotherapeutic treatments, a fusion of both methods is required, allowing bottom-up and top-down feedback.


Prof. A. Danani: Partecipazione a Modem (RSI Radio svizzera – Rete Uno)
Nanotecnologie: opportunità e rischi
Puntata del 4 giugno 2013
Link: Intervista a Modem-RSI

TITLE: Transcranial ultrasound (TUS) – A new therapy for brain disorders based on microtubule resonance?
SPEAKER: Stuart Hameroff – University of Arizona, Tucson, Arizona
DATE: Monday, June 3d, 2013
PLACE: Ospedale Civico Lugano, Neurocentro, Room 3, (floor -2)
TIME: 12.30 -13.30
“Consciousness in the Universe”
Public seminar of Prof. Stuart Hameroff
Date: Sunday, June 2nd 2013, 18:00
Place: Università della Svizzera Italiana, Room A11, Via Buffi 13, Lugano
Information: Seminar Hameroff June 2nd 2013
Link: Andrea Danani on Personalised Medicine – YouTube
Interviewed at the COST conference on Personalised Medicine, Andrea Danani, Professor, University Applied …
► 2:50
12/lug/2012 – Caricato da COSTOffice

LAMFI organized together with NAMED SA and Fondazione Canova the second international symposium entitled “Biophysical aspects of complexity in health ans disease”.

For more details for programs and speakers , see:

Press release Corriere del Ticino: (pdf)